Moreover, Manizales is, in the country, the city with the largest number of educational entities or artistic practice (visual arts, dance, theater, literature and music) registered per million of inhabitants (according to the Competitiveness Council 2008), and the Coffee-Grower axis is recognized as cultural and university region. The city has more than 100.000 students, 14 universities, 12 research and development institutes and the biggest Bioinformatics and Computational Biology Center for research and development in Latin America.